GLP-1 Peptides Compared: Semaglutide vs Tirzepatide vs Retatrutide

Quick Comparison

• Semaglutide: GLP-1 only (appetite, glucose).

• Tirzepatide: GLP-1 + GIP (adds insulin/lipid benefits).

• Retatrutide: GLP‑1 + GIP + glucagon (adds energy expenditure/fat oxidation).

Choosing for Research

• Semaglutide: Single-pathway mechanisms and established protocols.

• Tirzepatide: Dual-pathway synergy and improved outcomes.

• Retatrutide: Most comprehensive metabolic modulation.

Bottom line: Evolving from single → dual → triple receptor activation broadens metabolic leverage.