Semaglutide

Glucagon-like peptide-1 (GLP-1) is an endogenous peptide hormone secreted by the intestinal L-cells in response to nutrient intake. It is well-known for its role in glucose homeostasis by stimulating insulin secretion and inhibiting glucagon release in a glucose-dependent manner.

GLP-1 also slows gastric emptying, promoting satiety. As an incretin, it is often a target in the study of metabolic disorders, including diabetes and obesity. Its effects are mediated via the GLP-1 receptor, which is expressed in various tissues including the pancreas, brain, and gastrointestinal tract.