MOTS-C

MOTS-C is a mitochondrial-derived peptide that has gained attention for its role in regulating metabolic homeostasis, particularly in relation to glucose metabolism and insulin sensitivity. Unlike most peptides encoded by nuclear DNA, MOTS-C is encoded by the mitochondrial genome, highlighting its unique origin and function. This peptide influences metabolic pathways by activating the AMP-activated protein kinase (AMPK) pathway, a central regulator of cellular energy balance.

MOTS-C has been studied for its ability to enhance glucose uptake and promote fat oxidation, which makes it of interest in research on obesity, type 2 diabetes, and age-related metabolic decline. Additionally, MOTS-C’s involvement in stress resistance and mitochondrial function suggests it may play a protective role against cellular stress and metabolic dysfunction associated with aging.