Cagrilintide: The Appetite Control Peptide Nobody's Talking About (Yet)

The Other Appetite Hormone You've Never Heard Of

Cagrilintide is a long-acting amylin analog—working through amylin receptors (not GLP-1). Amylin is co-secreted with insulin when you eat and helps slow gastric emptying, suppress glucagon, and promote satiety.

Amylin 2.0

Cagrilintide is engineered for stability and consistent receptor activation:

• Extended half-life (days vs. minutes)

• Reduced aggregation tendency

• Reproducible signaling

How It Differs From GLP-1s

• Works via amylin receptors, not GLP-1

• Emphasizes meal termination (satisfied with smaller portions)

• Distinct brain pathways for satiety and food reward

Dual-Pathway Synergy (Cagrilintide + GLP-1)

Combining amylin and GLP-1 mechanisms can broaden appetite control and metabolic effects through complementary timing and receptors.

Research Considerations

• 99%+ purity and aggregation testing are critical

• Sensitive to handling; maintain cold chain and avoid repeated freeze–thaw

• Often used in combination protocols; timing matters

Bottom line: Cagrilintide opens a parallel satiety pathway that pairs well with GLP-1 strategies.