AOD-9604 vs GLP-1s: Different Approaches to Metabolic Support

Two Paths, One Goal

AOD‑9604 (GH fragment 177‑191) focuses on lipolysis and reduced lipogenesis with minimal systemic effects. GLP‑1 agonists modulate appetite, insulin, and gastric emptying for broader metabolic regulation.

When AOD‑9604 Shines

• Pure fat metabolism studies

• Situations avoiding appetite effects or insulin pathways

• Combination protocols (non‑overlapping mechanisms)

When GLP‑1s Lead

• Comprehensive metabolic change needed

• Appetite control is central

• Faster, larger effects acceptable

Combo Logic

• AM: AOD‑9604 (fasted)

• PM: GLP‑1 (e.g., Semaglutide/Retatrutide)

• Coverage across 24h with different levers

Bottom line: Scalpel vs. sledgehammer—choose the right tool, or use both strategically.